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Title 

Tungtungmadic acid, a novel antioxidant, from Salicornia herbacea

Authors 

Y C ChungHyo Kon ChunJae Young YangJ Y KimE H HanYung Hee KhoH G Jeong

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2005

Citation 

Archives of Pharmacal Research, vol. 28, no. 10, pp. 1122-1126

Keywords 

3-caffeoyl-4-dihydrocaffeoyl quinic acidantioxidant activitysalicornia herbaceatungtungmadic acidantioxidantchlorogenic acidplant extractamaranthaceaeanimalchemical structure

Abstract 

Tungtungmadic acid (3-caffeoyl-4-dihydrocaffeoyl quinic acid) is a new chlorogenic acid derivative that was isolated from the Salicornia herbacea. The structure of tungtungmadic acid was determined using chemical and spectral analysis. The antioxidant activity of tungtungmadic acid was evaluated using various antioxidant assays, including free radical scavenging, lipid peroxidation and hydroxyl radical-induced DNA strand breaks assays. Tungtungmadic acid (IC50 = 5.1 μM and 9.3 μM) was found to have higher antioxidant activity in the DPPH scavenging assay as well as in the iron-induced liver microsomal lipid peroxidation system. In addition, the tungtungmadic acid was also effective in protecting the plasmid DNA against strand breakage induced by hydroxyl radicals.

ISSN 

0253-6269

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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