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Title 

Fungal metabolites, sorbicillinoid polyketides and their effects on the activation of peroxisome proliferator-activated receptor γ

Authors 

Dongho LeeJeong-Hyung LeeX F CaiJin Chul ShinKyeong LeeYoung-Soo HongJung Joon Lee

Publisher 

Nature Publishing Group

Issue Date 

2005

Citation 

Journal of Antibiotics, vol. 58, no. 10, pp. 615-620

Keywords 

animal cellB lymphocytecell interactioncell motiondendritic celldynamicsB-Lymphocytescell communicationcell culture techniquesdendritic cells

Abstract 

A new sorbicillinoid polyketide, dihydrotrichodimerol (2), along with known trichodimerol (1), and rezishanones C (3) and D (4) were isolated by bioassay-guided fractionation from an unidentified fungal strain. Dihydrotrichodimerol (2) specifically activated peroxisome proliferator- activated receptor γ with an ED50 value of 80 ng/ml as measured by a transactivation assay using a chimeric hPPAR/GAL4 system without affecting peroxisome proliferator-activated receptors α and δ. On the other hand, compounds 1 and 2 suppressed the production of tumor necrosis factor-α and nitric oxide in LPS-stimulated RAW264.7 cells to a similar extent.

ISSN 

0021-8820

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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