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Title 

Sulfonamide chalcone as a new class of α-glucosidase inhibitors

Authors 

W D SeoJ H KimJ E KangH W RyuM J Curtis-LongHyun Sun LeeM S YangK H Park

Publisher 

Elsevier

Issue Date 

2005

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 15, no. 24, pp. 5514-5516

Keywords 

α-glucosidase inhibitoramylasechalconesulfonamide chalconealpha glucosidasealpha glucosidase inhibitorbeta amylasechalcone derivativesulfonamideamination

Abstract 

Chalcones 1-20, a new class of glycosidase inhibitors, were synthesized, and their glycosidase inhibitory activities were investigated. Non-aminochalcones 1-12 had no inhibitory activity, however, aminochalcones 13-20 had strong glycosidase (α-glucosidase, α-amylase, and β-amylase) inhibitory activities. In particular, sulfonamide chalcones 17-20 had more potent α-glucosidase inhibitory activity than aminated chalcone 13-16. 4′-(p-Toluenesulfonamide)-3,4-dihydroxy chalcone 20 (IC50 = 0.4 μM) was the best inhibitor against α-glucosidase, and these sulfonamide chalcones showed non-competitive inhibition.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2005.08.087

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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