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Title 

Apolipoprotein A-I induces IL-10 and PGE2 production in human monocytes and inhibits dendritic cell differentiation and maturation

Authors 

Kwang Dong KimHo Yong LimHee Gu LeeDo Young YoonYong Kyung ChoeIn Pyo ChoiS G PaikY S KimY YangJ S Lim

Publisher 

Elsevier

Issue Date 

2005

Citation 

Biochemical and Biophysical Research Communications, vol. 338, no. 2, pp. 1126-1136

Keywords 

apolipoprotein A-Idendritic cellsIL-10natural killer cellsPGE2apolipoprotein A1B7 antigenCD40 antigenCD86 antigencdia antigen

Abstract 

Apolipoprotein A-I (apoA-I), the major protein component of serum high-density lipoprotein, exhibits anti-inflammatory activity in atherosclerosis. In this study, we demonstrate that apoA-I inhibits DC differentiation and maturation. DC differentiated from monocytes in the presence of apoA-I showed a decreased expression of surface molecules such as CD1a, CD80, CD86, and HLA-DR. In addition, these DC exhibited decreased endocytic activity and weakened allogeneic T-cell activation. During DC differentiation in the presence of apoA-I, PGE2 and IL-10, which are known to be DC differentiation inhibitors and/or modulators of DC function, were produced at remarkable rates, whereas IL-12 production in the cells after stimulation with CD40 mAb and IFN-γ was significantly decreased in comparison with the control DC. T cells stimulated by apoA-I-pretreated DC produced significantly low levels of IFN-γ, and apoA-I inhibited cross-talk between DC and NK cells, in terms of IL-12 and IFN-γ production. Therefore, apoA-I appears to play an important role in modulating both innate immune response and inflammatory response. The novel inhibitory function of apoA-I on DC differentiation and function may facilitate the development of new therapeutic interventions in inflammatory diseases.

ISSN 

0006-291X

Link 

http://dx.doi.org/10.1016/j.bbrc.2005.10.065

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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