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Title 

Mouse models and the genetics of diabetes: is there evidence for genetic overlap between type 1 and type 2 diabetes?

Authors 

E H LeiterChul Ho Lee

Publisher 

American Diabetes Association

Issue Date 

2005

Citation 

Diabetes, vol. 54, no. S2, pp. S151-S158

Keywords 

animal modeldiabetes mellitusgenetic analysisgenetic susceptibilityinsulin dependent diabetes mellitusmolecular geneticsmousenon insulin dependent diabetes mellituscrosses, geneticdiabetes mellitus, type 1

Abstract 

In humans, both type 1 and type 2 diabetes exemplify genetically heterogeneous complex diseases in which epigenetic factors contribute to underlying genetic susceptibility. Extended human pedigrees often show inheritance of both diabetes types. A common pathophysiological denominator in both disease forms is pancreatic β-cell exposure to proinflammatory cytokines. Hence, it is intuitive that systemically expressed genes regulating β-cell ability to withstand chronic diabetogenic stress may represent a component of shared susceptibility to both major disease forms. In this review, the authors assemble evidence from genetic experiments using animal models developing clearly distinct diabetes syndromes to inquire whether some degree of overlap in genes contributing susceptibility can be demonstrated. The conclusion is that although overlap exists in the pathophysiological insults leading to β-cell destruction in the currently studied rodent models, the genetic bases seem quite distinct.

ISSN 

0012-1797

Link 

http://dx.doi.org/10.2337/diabetes.54.suppl_2.S151

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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