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Title 

Cyclic diarylheptanoids inhibit cell-mediated low-density lipoprotein oxidation

 

Cyclic diarylheptanoids의 항산화 효과

Authors 

Hyun Mi KangJu Ryong KimTae Sook JeongSung Gyu ChoiY H RyuG T OhN I BaekByoung-Mog Kwon

Publisher 

Taylor & Francis

Issue Date 

2006

Citation 

Natural Product Research, vol. 20, no. 2, pp. 139-143

Keywords 

alnus japonicadiarylheptanoidslow-density lipoprotein oxidationlow density lipoproteinlow density lipoprotein receptorhuman celllipid oxidationlipid peroxidationlipoproteins, Ldl

Abstract 

Two cyclic diarylheptanoids, garugamblin-3 (1) and acerogenin L (2), isolated from the MeOH extract of the fruits of Alnus japonica Steud., inhibited human low-density lipoprotein (LDL) oxidation in the thiobarbituric acid-reactive substance assay with IC 50 values of 2.9 and 1.7 μM, respectively, and they also inhibited cell-mediated LDL oxidation more than five times more strongly than that of a well-known antioxidant, probucol, at a concentration of 10 μM. 1 had no effect on the anti-atherogenesis in low-density lipoprotein receptor- deficient mice.

ISSN 

1478-6419

Link 

http://dx.doi.org/10.1080/14786410500045895

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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