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Title 

New cytotoxic benzopyrans from the leaves of Mallotus apelta

Authors 

P V KiemN H DangH V BaoH T HuongC V MinhL M HuongJung Joon LeeY H Kim

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2005

Citation 

Archives of Pharmacal Research, vol. 28, no. 10, pp. 1131-1134

Keywords 

benzopyrancytotoxic activityeuphorbiaceaemallotus apeltaplant leafbenzopyransplant leaves

Abstract 

Two new benzopyrans 6-[1′-oxo-3′(R)-hydroxy-butyl]-5,7- dimethoxy-2,2-dimethyl-2H-1-benzopyran (1) and 6-[1′-oxo-3′(R)- methoxy-butyl]-5,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran (2) were isolated from the leaves of Mallotus apelta Muell.-Arg., (Euphorbiaceae). Their chemical structures were elucidated by spectroscopic analyses, especially by 1D-, 2D-NMR and MS spectra. Compound 1 was found to have strong cytotoxic effect against two human cancer cell lines as human hepatocellular carcinoma (Hep-2, IC 50: 0.49 μg/mL) and rhabdosarcoma (RD, IC50: 0.54 μg/mL), while compound 2 showed moderate activity against Hep-2 cell line (IC50, 4.22 μg/mL) by in vitro assay.

ISSN 

0253-6269

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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