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Title 

Identification of novel allele on the locus 47z (DXYS5) in the Korean population

 

한국인 집단에서 47z (DXYS5)좌위의 신규 대립형질 발견

Authors 

Sung-Hwa ChaeJeong-Mo KimIl-Chul KimHan-Ho ChoiSang-Haeng ChoiD W KimSukhoon KohHwayong ParkHong-Seog Park

Publisher 

Springer Verlag (Germany)

Issue Date 

2005

Citation 

Journal of Human Genetics, vol. 50, no. 12, pp. 664-666

Keywords 

allele frequencyDXYS5Korean populationnovel allelepolymorphismallelegene identificationpolymorphic locuspopulation genetics

Abstract 

Two homogenous sequences of 47z (DXYS5) are located on the X (DXYS5X) and Y (DXYS5Y) chromosomes, and these are known to be useful polymorphic markers for tracing male-specific gene flow such as the migration routes of human populations. Using the 47z/StuI PCR-RFLP system, we found a novel allele which showed two bands, in contrast to the previous two allele types, one band (Y1) and three bands (Y2). This means that copies of PCR products derived from both the DXYS5X and DXYS5Y loci were clearly cut by the StuI enzyme, implying that the DXYS5X locus of the X chromosome is polymorphic. Allelic frequencies examined in 267 male Korean individuals showed that 95.8% had Y1, 3.4% Y2, and 0.8% had the novel allele. Our findings should contribute to a better understanding of genetic polymorphism on X and Y chromosomes, the molecular evolution mechanism of sex chromosomes, and how the migration route of Koreans is related to those of other East Asian populations.

ISSN 

1435-232X

Link 

http://dx.doi.org/10.1007/s10038-005-0305-1

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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