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Title 

Transgenic potato expressing Aβ reduce Aβ burden in Alzheimer's disease mouse model

Authors 

Jung Won YoumH KimJ H L HanC H JangH J HaI Mook-JungJae Heung JeonC Y ChoiY H KimHyun Soon KimHyouk Joung

Publisher 

Elsevier

Issue Date 

2005

Citation 

FEBS Letters, vol. 579, no. 30, pp. 6737-6744

Keywords 

alzheimer's diseasebeta amyloidoral immunizationpotatotransgenic plantamyloid beta proteinalzheimer diseaseanimal experimentbraincontrolled study

Abstract 

Beta amyloid (Aβ) is believed one of the major pathogens of Alzheimer's disease (AD), and the reduction of Aβ is considered a primary therapeutic target. Immunization with Aβ can reduce Aβ burden and pathological features in transgenic AD model mice. Transgenic potato plants were made using genes encoding 5 tandem repeats of Aβ1-42 peptides with an ER retention signal. Amyloid precursor protein transgenic mice (Tg2576) fed with transgenic potato tubers with adjuvant showed a primary immune response and a partial reduction of Aβ burden in the brain. Thus, Aβ tandem repeats can be expressed in transgenic potato plants to form immunologically functional Aβ, and these potatoes has a potential to be used for the prevention and treatment of AD.

ISSN 

0014-5793

Link 

http://dx.doi.org/10.1016/j.febslet.2005.11.003

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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