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Title 

T lymphocytes and dendritic cells are activated by the deletion of peroxiredoxin II (Prx II) gene

 

퍼록시레독신 II 결손에 의한 T 임파구와 DC의 활성화 연구

Authors 

Eun Yi MoonY W NohYing Hao HanSun-Uk KimJ M KimDae Yeul YuJ S Lim

Publisher 

Elsevier

Issue Date 

2006

Citation 

Immunology Letters, vol. 102, no. 2, pp. 184-190

Keywords 

dendritic cellperoxiredoxin II (Prx II)reactive oxygen species (ROS)T lymphocyteCD3 antigenglycoprotein p 15095peroxiredoxinprotein peroxiredoxin IIanimal cellbone marrow cell

Abstract 

Peroxiredoxin II (Prx II) is a member of antioxidant enzyme family and it plays a protective role against oxidative damage. Constitutive production of endogenous reactive oxygen species was detected in spleen and bone marrow cells lacking Prx II. Here, we investigated the role of Prx II in immune responses. The total number of splenocytes (especially, the population of S-phase cells and CD3+ T cells) was significantly higher in Prx II-/- mice than in wild type. Number of peripheral blood mononuclear cells (PBMCs) in Prx II-/- mice was also higher than wild type. Differentiation of Prx II-/- mouse bone marrow cells into CD11c-positive dendritic cells was greater than that of wild type. Transplantation of Prx II-/- bone marrow cells into wild type mice increased PBMCs in blood and bone marrow-derived dendritic cells. Prx II deletion enhances concanavalin A (ConA)-induced splenocyte proliferation and mixed lymphocyte reaction (MLR) activity of bone marrow-derived CD11c-positive dendritic cells to stimulate recipient splenocytes. Collectively, these data suggest that Prx II inhibits the immune cell responsiveness, which may be regulated by scavenging the low amount of reactive oxygen species (ROS).

ISSN 

0165-2478

Link 

http://dx.doi.org/10.1016/j.imlet.2005.09.003

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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