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Title 

Comparative genomics study of interferon-α receptor-1 in humans and chimpanzees

 

사람과 침팬지의 Interferon-α Receptor-1 비교 분석

Authors 

Il Chul KimSeung-Wook ChiDae Won KimSang-Haeng ChoiSung Hwa ChaeHong-Seog Park

Publisher 

Korea Genome Organization

Issue Date 

2005

Citation 

Genomics & Informatics, vol. 3, no. 4, pp. 142-148

Keywords 

chimpanzee genomecomparative genomicsinterferon-a receptorevolutioninsertion

Abstract 

The immune response-related genes have been suggested to be the most favorable genes for positive selection during evolution. Comparing the entire DNA sequence of chimpanzee chromosome 22 (PTR22) with human chromosome 21 (HSA21), we have identified 15 orthologs having indel in their coding sequences. Among them, interferon-.... receptor-1 gene (IFNAR1), an immuneresponse- related gene, is subjected to comparative genomic analysis. Chimpanzee IFNAR1 showed the same genomic structure as human IFNAR1 (11 exons and 10 introns) except the 3 bp insertion in exon 4. The sequence alignment of IFNAR1 coding sequence indicated that “ISPP” amino acid sequence motif is highly conserved in chimpanzee and other animals including mouse and chicken. However, the human IFNAR1 shows that one proline residue is missing in the sequence motif. The homology modeling of the IFNAR1 structures suggests that the proline deletion in human IFNAR1 leads to the formation of the following ..-helix, whereas two sequential prolines in chimpanzee IFNAR1 inhibit it. As a result, human IFNAR1 may adopt a characteristic structure distinct from chimpanzee IFNAR1. This human specific trait could contribute to specific immune response in the most optimized manner for humans. Further molecular biological studies on the IFNAR1 will help us to gain insights into the molecular implication of speciesspecific host-pathogen interaction in primate evolution.

ISSN 

1598-866X

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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