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Title 

Monoamine oxidase inhibitory constituents from the fruits of Cudrania tricuspidata

Authors 

X H HanS S HongJ S HwangS H JeongJ H HwangM H LeeM K LeeDongho LeeJ S RoB Y Hwang

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2005

Citation 

Archives of Pharmacal Research, vol. 28, no. 12, pp. 1324-1327

Keywords 

cudrania tricuspidatagancaonin Amonoamine oxidase inhibitormoraceaeprenylated isoflavoneamine oxidase (flavin containing)fruitmonoamine oxidasemonoamine oxidase inhibitors

Abstract 

A methylene chloride soluble fraction of the fruits of Cudrania tricuspidata significantly inhibited the mouse brain monoamine oxidase (MAO). Three known prenylated isoflavones were isolated and identified by activity-guided fractionation. Gancaonin A (1), 4′-O- methylalpinumisoflavone (2), and alpinumisoflavone (3) inhibited MAO activity in a concentration-dependent manner with IC50 values of 19.4, 23.9, and 25.8 μM, respectively. of these, gancaonin A (1) showed a selective and potent inhibitory effect against MAO-B (IC50 0.8 μM) than MAO-A (IC50 >800 μM). The kinetic analysis using Lineweaver-Burk plots indicated that gancaonin A (1) competitively inhibited MAO-B.

ISSN 

0253-6269

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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