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Title 

Phenolic constituents with inhibitory activity against NFAT transcription from Desmos chinensis

Authors 

P V KiemC V MinhH T HuongJung Joon LeeI S LeeY H Kim

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2005

Citation 

Archives of Pharmacal Research, vol. 28, no. 12, pp. 1345-1349

Keywords 

desmos chinensisNFAT transcription factorphenolic constituentstranscription factor NFATinhibitory concentration 50NFATC transcription factors

Abstract 

Six phenolic constituents, 2-methoxybenzyl benzoate (1), negletein (2), 2′,3′-dihydroxy-4′,6′-dimethoxydihydrochalcone (3), 5,6-dihydroxy-7-methoxy-dihydroflavone (4), astilbin (5), and quercitrin (6) were isolated from the methanol extract of the dried leaves of Desmos chinensis. Their structures were elucidated from spectral and chemical data. of these constituents, compounds 2 (IC50: 3.89 ± 0.39 μM) and 3 (IC50: 9.77 ± 0.26 μM) exhibited potent inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor, and compound 1 (IC50: 28.4 ± 2.62 μM) exhibited moderate inhibitory activity.

ISSN 

0253-6269

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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