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Title 

Protein tyrosine phosphatase 1B inhibitors from Morus root bark

Authors 

L CuiMin Kyun NaH OhEun Young BaeDae Gwin JeongSeong Eon RyuS KimBo Yeon KimWon Keun OhJong Seog Ahn

Publisher 

Elsevier

Issue Date 

2006

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 16, no. 5, pp. 1426-1429

Keywords 

kuwanon L.morus root barkmulberrofuran Cprotein tyrosine phosphatase 1Bsanggenon Csanggenon Gprotein tyrosine phosphatase inhibitorplant rootenzyme inhibitorsinhibitory concentration

Abstract 

An organic layer prepared from the Chinese crude drug 'Sang-Bai-Pi' (Morus root bark) was studied in order to identify the inhibitory compounds for protein tyrosine phosphatase 1B (PTP1B). Bioassay-guided fractionation resulted in the isolation of sanggenon C (1), sanggenon G (2), mulberrofuran C (3) and kuwanon L (4) as PTP1B inhibitors, along with moracin O (5) and moracin P (6). Compounds 1-4 inhibited PTP1B with IC50 values ranging from 1.6 ± 0.3 μM to 16.9 ± 1.1 μM.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2005.11.071

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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