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Title 

Human ACAT-1 and ACAT-2 inhibitory activities of pentacyclic triterpenes from the leaves of Lycopus lucidus Turcz.

 

택란 잎으로부터 분리한 pentacyclic triterpenes의 사람 ACAT-1과 ACAT-2 저해 활성

Authors 

Woo Song LeeKyung Ran ImYong Dae ParkN D SungTae Sook Jeong

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2006

Citation 

Biological & Pharmaceutical Bulletin, vol. 29, no. 2, pp. 382-384

Keywords 

Acyl-CoAatherosclerosischolesterol acytransferase (ACAT)lycopus luciduspentacyclic triterpenecholesterol acyltransferase 1cholesterol acyltransferase 2enzyme activitylycopus

Abstract 

Acyl-CoA: cholesterol acyltransferase (ACAT) catalyzes the acylation of cholesterol to cholesteryl ester with long chain fatty acids and ACAT inhibition is a useful strategy for treating hypercholesterolemia or atherosclerosis. Pentacyclic triterpenes, ursolic acid (1), oleanolic acid (2), and betulinic acid (3) were isolated from the methanol extracts of the leaves of Lycopus lucidus TURCZ. by bioassay-guided fractionation. The structures of compounds 1-3 were elucidated by their spectroscopic data analysis. Among them, betulinic acid (3) exhibited more potent human ACAT-1 and ACAT-2 inhibitory activities with IC50 values of 16.2±0.6 and 28.8±1.3 μM, respectively.

ISSN 

0918-6158

Link 

http://doi.org/10.1248/bpb.29.382

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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