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Title 

Biosynthesis of the heat shock protein 90 inhibitor geldanamycin: new insight into the formation of benzoquinone moiety

Authors 

D LeeKyeong LeeX F CaiN T DatS K BoovanahalliMijeoung LeeJin Chul ShinWon Cheol KimJae Kap JeongJong Suk LeeChoong Hwan LeeJeong-Hyung LeeYoung-Soo HongJung Joon Lee

Publisher 

Wiley-Blackwell

Issue Date 

2006

Citation 

ChemBioChem, vol. 7, no. 2, pp. 246-248

Keywords 

antitumor agentsautooxidationbiosynthesispolyketidesbenzoquinonegeldanamycinheat shock protein 90 inhibitorbiotransformationbenzoquinonesHSP90 heat-shock proteins

Abstract 

A clue towards determining the biosynthetic origin of ansamycin benzoquinone formation by spontaneous oxidation from a corresponding hydroquinone has been provided by ACDL3172 (1), a tricyclic geldanamycin derivative produced by the gel8 gene-inactivated strain of S. hygroscopicus subsp. duamyceticus JCM4427.

ISSN 

1439-4227

Link 

http://dx.doi.org/10.1002/cbic.200500441

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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