상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Inhibitory activity of 6-O-angeloylprenolin from Centipeda minima on farnesyl protein transferase

 

식물체로부터 FPTase 저해제 분리

Authors 

Hyun Mi OhByoung-Mog KwonN I BaekS H KimJ H LeeJ S EunJ H YangD K Kim

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2006

Citation 

Archives of Pharmacal Research, vol. 29, no. 1, pp. 64-66

Keywords 

6-O-Angeloylprenolincentipeda minimaFPTase6 O angeloylprenolin6-O-angeloylprenolinenzyme inhibitorfarnesyl trans transferasefused heterocyclic ringsmethanolsolvent

Abstract 

The methanolic extract of the aerial parts of Centipeda minima was found to show inhibitory activity on famesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of 6-O-angeloylprenolin, as an inhibitor on FPTase. This compound inhibited FPTase activity in a dose-dependent manner, and the IC50 value of 6-O-angeloylprenolin was 18.8 μM.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/BF02977470

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)