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Title 

Acidic polysaccharide from Phellinus linteus inhibits melanoma cell metastasis by blocking cell adhesion and invasion

Authors 

Sang Bae HanChang Woo LeeJong Soon KangYeo Dae YoonKi Hoon LeeKiho LeeSong Kyu ParkHwan Mook Kim

Publisher 

Elsevier

Issue Date 

2006

Citation 

International Immunopharmacology, vol. 6, no. 4, pp. 697-702

Keywords 

adhesioninvasionmetastasisphellinus linteusphellinus linteus extractpolysaccharideanimal cellcell adhesioncell invasionextracellular matrix

Abstract 

The acidic polysaccharide (PL) from Phellinus linteus is an immunostimulator that has therapeutic activity against cancers. Here, we show that PL markedly inhibits melanoma cell metastasis in mice, and report that PL directly inhibits cancer cell adhesion to and invasion through the extracellular matrix, but that it has no direct effect on cancer cell growth. In addition, we found that PL increased macrophage NO production. These results suggest that PL has two antimetastatic functions, i.e., it acts as an immunopotentiator and as a direct inhibitor of cancer cell adhesion.

ISSN 

1567-5769

Link 

http://dx.doi.org/10.1016/j.intimp.2005.10.003

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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