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Title 

Cosmeceutical properties of levan produced by Zymomonas mobilis

Authors 

Chul Ho Kim

Publisher 

Society of Cosmetic Chemists

Issue Date 

2005

Citation 

Journal of Cosmetic Science, vol. 56, no. 6, pp. 395-406

Keywords 

levanzymomonas

Abstract 

Levan, a polysaccharide that can be produced by both plants and microorganisms, is a sugar polymer composed of fructose, with β-2,6 linkages. Here, we have attempted to assess the possible use of levan produced by Zymomonas mobilis as a cosmeceutical ingredient. In service of this goal, we assessed a host of levan's properties, including its moisturizing effects, cell cytotoxicity, cell proliferation effects, and anti-inflammation effects. Levan exhibited a moisturizing effect that was almost exactly the same as that evidenced by hyaluronic acid, as well as a similar cell proliferation effect in human fibroblast and keratinocyte cell lines. Moreover, in our cell proliferation test, which was conducted using bio-artificial skin constructed via 3-dimensional (3-D) culture after the induction of primary skin inflammation with 0.05% sodium lauryl sulfate (SLS), cell viability in the presence of levan (0.01 mg/ml, 0.05 mg/ml) was determined to be higher than cell viability in the absence of levan. In our anti-inflammation test, which was also conducted using 3-D artificial skin, and which involved the measurement of a quantity of secreted interleukin-1α (IL-1α), a pre-inflammatory mediator induced by SLS, we determined that the quantity of IL-1α in the 3-D artificial skin treated with 0.01 mg/ml and 0.05 mg/ml of levan was less than that registered in a skin sample that had been treated only with SLS. In this study, we determined that levan exerted an anti-inflammatory effect against inflammatory reactions to skin irritants, and also that levan exerted a cell-proliferative effect in bio-artificial skin, thereby indicating its potential applicability as a cosmeceutical agent.

ISSN 

1525-7886

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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