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Title 

Human chromosome 11 DNA sequence and analysis including novel gene identification

Authors 

T D TaylorH NoguchiY TotokiA ToyodaY KurokiDae-Won KimHong-Seog ParkM HattoriJ RogersE S LanderY Sakaki

Publisher 

Nature Publishing Group

Issue Date 

2006

Citation 

Nature, vol. 440, no. 7083, pp. 497-500

Keywords 

DNA sequencesgeneshuman genomeprotein-coding geneschromosomeschromosomechromosome 11chromosome analysisDNA determinationgene cluster

Abstract 

Chromosome 11, although average in size, is one of the most gene- and disease-rich chromosomes in the human genome. Initial gene annotation indicates an average gene density of 11.6 genes per megabase, including 1,524 protein-coding genes, some of which were identified using novel methods, and 765 pseudogenes. One-quarter of the protein-coding genes shows overlap with other genes. of the 856 olfactory receptor genes in the human genome, more than 40% are located in 28 single- and multi-gene clusters along this chromosome. Out of the 171 disorders currently attributed to the chromosome, 86 remain for which the underlying molecular basis is not yet known, including several mendelian traits, cancer and susceptibility loci. The high-quality data presented here - nearly 134.5 million base pairs representing 99.8% coverage of the euchromatic sequence - provide scientists with a solid foundation for understanding the genetic basis of these disorders and other biological phenomena.

ISSN 

0028-0836

Link 

http://dx.doi.org/10.1038/nature04632

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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