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Title 

Antioxidant effects of quinoline alkaloids and 2,4-Di-tert-butylphenol isolated from Scolopendra subspinipes

 

지네로부터 분리한 퀴놀린 알카로이드 및 2,4-디-티부탄올의 항산화 효과

Authors 

Mi-Ae YoonTae Sook JeongDoo Sang ParkM Z XuHyun Woo OhK B SongWoo Song LeeHo Yong Park

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2006

Citation 

Biological & Pharmaceutical Bulletin, vol. 29, no. 4, pp. 735-739

Keywords 

2,4-di-tert-butyl-phenol3,8-dihydroxyquinolineantioxidantlow-density lipoprotein (LDL)scolopendra subspinipes2,4 di(tert butyl)phenol2,8 dihydroxy 3,4 dimethoxyquinoline3,8 dihydroxyquinolinealkaloid derivativeoxidized low density lipoprotein

Abstract 

The oxidized low-density lipoprotein (ox-LDL) plays a critical role at the early stages of atherosclerosis. Thus, the prevention of LDL-oxidation by antioxidants may arrest the progression of atherosclerosis. Two quinoline alkaloids, 3,8-dihydroxyquinoline (1) and 2,8-dihydroxy-3,4-dimethoxyquinoline (3), and 2,4-di-tert-butylphenol (2) were isolated from the dried body of Scolopendra subspinipes. Compounds 1-3 exhibited antioxidant activities on copper-mediated (1: IC50=2.6 μM, 2: IC50=8.2 μM, 3: IC50=63.0 μM), AAPH-mediated oxidation (1: IC50=3.9 μM, 2: IC50=9.9 μM, 3: IC50=71.8 μM), and SIN-1-mediated oxidation (1: 70%, 2: 52%, 3: 29% at 5.0 μM) in the TBARS assay. The antioxidant activities of compounds 1-3 were tested with respect to other parameters, such as the lag time of conjugated diene fromation, relative electrophoretic mobility (REM) of ox-LDL, and apoB-100 fragmentation on copper-mediated LDL-oxidation. In addition, compounds 1-3 showed 1,1-diphenyl-2-picrylhydrasyl (DPPH) radical scavenging activity and compound 1 also exhibited metal chelating activity.

ISSN 

0918-6158

Link 

http://dx.doi.org/10.1248/bpb.29.735

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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