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Title 

A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells

 

Hepatic progenitor 셀에서 유래된 간세포암의 새로운 subtype 동정

Authors 

J S LeeJ HeoL LibbrechtIn-Sun ChuP Kaposi-NovakD F CalvisiA MikaelyanL R RobertsA J DemetrisZ SunF NevensT RoskamsS S Thorgeirsson

Publisher 

Nature Publishing Group

Issue Date 

2006

Citation 

Nature Medicine, vol. 12, no. 4, pp. 410-416

Keywords 

adultanimal cellanimal experimentanimal modelapoptosiscancer invasioncarcinogenesiscell proliferationfemalefetus cell

Abstract 

The variability in the prognosis of individuals with hepatocellular carcinoma (HCC) suggests that HCC may comprise several distinct biological phenotypes. These phenotypes may result from activation of different oncogenic pathways during tumorigenesis and/or from a different cell of origin. Here we address whether the transcriptional characteristics of HCC can provide insight into the cellular origin of the tumor. We integrated gene expression data from rat fetal hepatoblasts and adult hepatocytes with HCC from human and mouse models. Individuals with HCC who shared a gene expression pattern with fetal hepatoblasts had a poor prognosis. The gene expression program that distinguished this subtype from other types of HCC included markers of hepatic oval cells, suggesting that HCC of this subtype may arise from hepatic progenitor cells. Analyses of gene networks showed that activation of AP-1 transcription factors in this newly identified HCC subtype might have key roles in tumor development.

ISSN 

1078-8956

Link 

http://dx.doi.org/10.1038/nm1377

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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