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Title 

Growth inhibitory effect of triple anti-tumor gene transfer using Semliki Forest virus vector in glioblastoma cells

 

Glioblastoma의 유전자 치료

Authors 

J S LeeJ H LeeHaryoung PooM S KimS H LeeM H SungC J Kim

Publisher 

Spandidos Publications

Issue Date 

2006

Citation 

International Journal of Oncology, vol. 28, no. 3, pp. 649-654

Keywords 

cell linecell proliferationcell survivalgene therapygene vectorgenetic transfectiongeneticsglioblastomasemliki forest alphavirustumor cell line

Abstract 

The gene delivery of multiple tumor suppressors can provide an efficient tumor therapy in the case of malignant human glioblastomas containing multiple genetic alteration and inactivation. As such, the current study presents a new delivery system that can simultaneously express three anti-tumor genes using a Semliki Forest virus (SFV) vector in the expectation of combined or synergistic effects of angiogenesis inhibition by angiostatin and apoptosis induction by p53, PTEN and the rSFV particle itself. Recombinant SFV (rSFV) containing three anti-tumor genes (rSFV-Agt/p53/PTEN) were found to efficiently transduce and express each anti-tumor gene in glioblastoma cells. In addition, rSFV-Agt/p53/PTEN also resulted in a more effective induction of apoptosis in vitro and inhibition of tumor growth in nude mice when compared with other rSFVs containing only one or two anti-tumor genes. Accordingly, the current results demonstrate that a triple anti-tumor gene transfer using an rSFV vector would be a powerful strategy for regional cancer gene therapy.

ISSN 

1019-6439

Link 

http://dx.doi.org/10.3892/ijo.28.3.649

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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