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Title 

Acyl-CoA: cholesterol acyltransferase inhibitors from Ilex macropoda

 

대패집나무로부터 분리한 ACAT 저해제

Authors 

K R ImTae Sook JeongByoung-Mog KwonN I BaekS H KimD K Kim

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2006

Citation 

Archives of Pharmacal Research, vol. 29, no. 3, pp. 191-194

Keywords 

ACAT inhibitory activitybetulinIlex macropodalupeolcholesterol acyltransferaseenzyme inhibitorhypocholesterolemic agentsterol O acyltransferase 1sterol O acyltransferase 2Ilex

Abstract 

Twigs from Ilex macropoda were extracted with MeOH, and the concentrated extracts were partitioned with CH2Cl2, EtOAc, n-BuOH, and H2O. Repeated column chromatography of the CH2Cl 2 fraction ultimately resulted in the isolation of two compounds, via activity-guided fractionation, using ACAT inhibitory activity measurements. According to the physico-chemical data, the chemical structures of these isolated compounds were identified as lupeol (1) and betulin (2). Compounds 1 and 2 were shown to inhibit the activity of hACAT-1 and hACAT-2 in a dose-dependent manner, and compounds 1 and 2 inhibited hACAT-1 with IC50 values of 48 and 83 μM, respectively.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/BF02969391

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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