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Title 

Functional annotation and analysis of Korean patented biological sequences using bioinformatics

 

생물정보기법을 이용한 한국 특허서열의 분석

Authors 

ByungUk LeeTae Hyung KimSeon-Kyu KimS S KimGee Chan RyuJong Bhak

Publisher 

Springer Verlag (Germany)

Issue Date 

2006

Citation 

Molecules and Cells, vol. 21, no. 2, pp. 269-275

Keywords 

BLAST analysisGene-, disease-, pathway-, and biofunction-patent association mapsKorea patented biological sequencesRefSeqbioinformaticscorrelation analysisdata analysisgene sequencenucleotide sequencebase sequence

Abstract 

A recent report of the Korean Intellectual Property Office (KIPO) showed that the number of biological sequence-based patents is rapidly increasing in Korea. We present biological features of Korean patented sequences though bioinformatic analysis. The analysis is divided into two steps. The first is an annotation step in which the patented sequences were annotated with the Reference Sequence (RefSeq) database. The second is an association step in which the patented sequences were linked to genes, diseases, pathway, and biological functions. We used Entrez Gene, Online Mendelian Inheritance in Man (OMIM), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene Ontology (GO) databases. Through the association analysis, we found that nearly 2.6% of human genes were associated with Korean patenting, compared to 20% of human genes in the U.S. patent. The association between the biological functions and the patented sequences indicated that genes whose products act as hormones on defense responses in the extra-cellular environments were the most highly targeted for patenting. The analysis data are available at http://www.patome.net.

ISSN 

1016-8478

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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