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Title 

Suppressive effect of verproside isolated from Pseudolysimachion longifolium on airway inflammation in a mouse model of allergic asthma

 

긴산꼬리풀에서 추출한 verproside의 알러지성 천식 동물모델 염증

Authors 

Sei Ryang OhMee Young LeeKyung Seop AhnB Y ParkOk Kyong KwonHyouk JoungJoongku LeeDoo-Young KimSangku LeeJ H KimHyeong Kyu Lee

Publisher 

Elsevier

Issue Date 

2006

Citation 

International Immunopharmacology, vol. 6, no. 6, pp. 978-986

Keywords 

allergic asthmamouse modelpseudolysimachion longifoliumverprosideantiasthmatic agentherbaceous agentmontelukastovalbuminpseudolysimachion longifolium extractunclassified drug

Abstract 

Allergic inflammation of the airways has a critical role in asthma development. We investigated a suppressive effect of verproside (3,4-dihydroxy catalpol) isolated from the extract of Pseudolysimachion longifolium on asthmatic parameters-such as immunoglobulin E (IgE) level, cytokine release, eosinophilia, airway hyperresponsiveness and mucus hypersecretion-in an OVA-sensitized/challenged mouse model. Verproside significantly inhibited the increase of total IgE and the cytokines IL-4 and IL-13 in plasma and bronchoalveolar lavage fluid, and also effectively suppressed airway hyperresponsiveness, eosinophilia and mucus hypersecretion in OVA-induced asthmatic mice. The efficacy of verproside was comparable to montelukast, an anti-asthmatic drug that is currently available. These results suggest that verproside could be a major marker in herbal medicines that are used for asthma treatment, and could also act as a lead for anti-asthmatic drugs.

ISSN 

1567-5769

Link 

http://dx.doi.org/10.1016/j.intimp.2006.01.010

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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