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Title 

Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags

Authors 

A G WangS Y YoonJ H OhYeo-Jin JeonMirang KimJ M KimSang-Soon ByunJin Ok YangJ H KimD G KimYoung Il YeomHyang Sook YooYong Sung KimNam-Soon Kim

Publisher 

Elsevier

Issue Date 

2006

Citation 

Biochemical and Biophysical Research Communications, vol. 345, no. 3, pp. 1022-1032

Keywords 

ESTs frequencyexpression profilingintrahepatic cholangiocarcinomaliverambp geneanxa1 geneanxa2 genecancer geneticsexpressed sequence taggene

Abstract 

Intrahepatic cholangiocarcinoma (ICC), a malignant tumor derived from the bile duct epithelium, is one of the leading causes of death from cancer, worldwide. However, the mechanisms related to it remain largely unknown. In this study, an analysis of the gene expression profiles for ICC was done using the frequency of the ESTs obtained from nine cDNA libraries that constructed from 4 ICC cell lines and 4 normal liver tissues. One hundred and thirty-seven genes were identified as being either up- or down-regulated in human ICC cells. Thirty genes were randomly selected to confirm their differential expression in 4 human ICC cell lines and 5 ICC tissues compared to normal liver tissues by semi-quantitative RT-PCR. Among these genes, ANXA1, ANXA2, AMBP, and SERPINC1 were further verified by immunohistochemical analyses. In conclusion, these identified genes represent potential biomarkers for ICC and represent potential targets for elucidating the molecular mechanisms that are associated with ICC.

ISSN 

0006-291X

Link 

http://dx.doi.org/10.1016/j.bbrc.2006.04.175

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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