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Title 

Streptokordin, a new cytotoxic compound of the methylpyridine class from a marine-derived Streptomyces sp. KORDI-3238

Authors 

S Y JeongH J ShinT S KimH S LeeSong Kyu ParkHwan Mook Kim

Publisher 

Nature Publishing Group

Issue Date 

2006

Citation 

Journal of Antibiotics, vol. 59, no. 4, pp. 234-240

Keywords 

16S rDNA4-acetyl-6-methyl-1-H-pyridine-2-onecytotoxicmethylpyridinestreptomyces sp. KORDI-3238acidcytotoxic agentdilactonelactone derivativenonactic acid

Abstract 

A new cytotoxic compound, streptokordin, and four known compounds, nonactic acid, dilactone, trilactone, and nonactin, were isolated from the fermentation broth of a marine actinomycete strain collected in deep-sea sediments. Biochemical tests and 16S rDNA analysis indicated that the strain belongs to the genus Streptomyces. This actinomycete produces various bioactive secondary metabolites. Fractionations by solvent partitioning, silica vacuum flash chromatography, and reversed-phase HPLC gave a pure cytotoxic compound, designated streptokordin. Its structure was elucidated by FAB-MS, 1H, 13C, and 2D NMR spectroscopy. Streptokordin exhibited significant cytotoxicity against seven human cancer cell lines but showed no growth inhibition against various microorganisms including bacteria and fungi.

ISSN 

0021-8820

Link 

http://dx.doi.org/10.1038/ja.2006.33

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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