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Title 

Idescarpin isolated from the fruits of Idesia polycarpa inhibits melanin biosynthesis

Authors 

Seunghwa BaekD KimC LeeYung Hee KhoChoong Hwan Lee

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

2006

Citation 

Journal of Microbiology and Biotechnology, vol. 16, no. 5, pp. 667-672

Keywords 

idescarpinidesia polycarpamelana cellmelanin biosynthesis inhibitorskin-whiteningtyrosinaseidesia polycarpa extractmelaninfruit

Abstract 

Tyrosinase is an enzyme that catalyzes the biosynthetic pathway of melanin pigments participating in the coloring of skin, hair, and eyes, and is widely distributed in nature. The inhibitory compounds of tyrosinase have been extensively used as a cosmetic agent with a skin-whitening effect. In this paper, several plant extracts were screened using Melan-a cells for the melanin biosynthesis inhibition activity, and Idesia polycarpa was selected. A melanin biosynthesis inhibitor was isolated from I. polycarpa fruits by activity-guided fractionation, and the inhibitor was identified as 6-hydroxy-2- [(1-hydr oxy-6-oxo-2-cyclohexen-1-yl)carbonyl]oxy]methyl]phenyl β-D-glucopyranoside (idescrapin) by comparing it with reported spectral data. Idescarpin (IC50 = 8 μg/ml) reduced melanin content compared with the vehicle. In addition, the inhibitory activity of idescarpin for melanin synthesis is mediated by decreasing tyrosinase protein rather than directly inhibiting the tyrosinase activity. These results suggest that idescarpin isolated from I. polycarpa fruits may be used as a skin-whitening agent.

ISSN 

1017-7825

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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