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Title 

Diagnostic accuracy of serum asialo-α(1)-acid glycoprotein concentration for the differential diagnosis of liver cirrhosis and hepatocellular carcinoma

 

간암과 간경변 감별용 진단의 정확성

Authors 

Kyung A KimE Y LeeJ H KangHee Gu LeeJae Wha KimDur Han KwonY J JangYoung Il YeomT W ChungY D KimD Y YoonEun Young Song

Publisher 

Elsevier

Issue Date 

2006

Citation 

Clinica Chimica Acta, vol. 369, no. 1, pp. 46-51

Keywords 

antibody-lectin sandwich assayasialo-α1-acid glycoproteinasialoglycoproteinshepatic disease serum markerhepatocellular carcinomaliver cirrhosisasialo alpha acid glycoproteinglycoproteincancer diagnosisdiagnostic accuracy

Abstract 

Background: Serum asialoglycoproteins concentration are increased in patients with hepatic disease. We developed an antibody-lectin sandwich assay that is sensitive and specific to measure asialo-α1-acid glycoprotein (AsAGP) concentration in human serum and evaluated it as a biochemical marker for hepatic disease. Methods: Serum AsAGP concentration was measured by antibody-lectin sandwich assay with 610 serum specimens of patients with hepatic disease. Serum from 41 healthy donors and 155 patients with non-hepatic disease served as negative controls. The AsAGP values were analyzed by receiver operator characteristics (ROC) curve analysis. The diagnostic accuracy of AsAGP value was compared with those of the conventional biochemical markers in the liver function test. Results: Serum AsAGP concentration in 83% of patients with liver cirrhosis (LC) and 89% of patients with hepatocellular carcinoma (HCC) was increased over the cutoff value (1.33 μg/ml), indicating that an increase of serum AsAGP concentration is restricted to LC or HCC cases. The area under curve (AUC) in the ROC curve was 0.919 for LC and 0.946 for HCC. Conclusions: Serum AsAGP concentration exhibited good diagnostic accuracy as a biochemical marker for LC and HCC. The addition of AsAGP to conventional liver function tests may significantly improve the diagnosis and prognosis.

ISSN 

0009-8981

Link 

http://dx.doi.org/10.1016/j.cca.2006.01.002

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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