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Title 

Line fusion genes: a database of LINE expression within human genes

Authors 

Dae Soo KimT H KimJ W HuhI C KimSeok Won KimHong-Seog ParkH S Kim

Publisher 

BioMed Central

Issue Date 

2006

Citation 

BMC Genomics, vol. 7, no. 0, pp. 139-139

Keywords 

messenger RNA3' untranslated region5' untranslated regionclassificationDNA integrationgene expression profilinggene locationgene structuregenetic databasehuman genome

Abstract 

Background: Long Interspersed Nuclear Elements (LINEs) are the most abundant retrotransposons in humans. About 79% of human genes are estimated to contain at least one segment of LINE per transcription unit. Recent studies have shown that LINE elements can affect protein sequences, splicing patterns and expression of human genes. Description: We have developed a database, LINE FUSION GENES, for elucidating LINE expression throughout the human gene database. We searched the 28,171 genes listed in the NCBI database for LINE elements and analyzed their structures and expression patterns. The results show that the mRNA sequences of 1,329 genes were affected by LINE expression. The LINE expression types were classified on the basis of LINEs in the 5′ UTR, exon or 3′ UTR sequences of the mRNAs. Our database provides further information, such as the tissue distribution and chromosomal location of the genes, and the domain structure that is changed by LINE integration. We have linked all the accession numbers to the NCBI data bank to provide mRNA sequences for subsequent users. Conclusion: We believe that our work will interest genome scientists and might help them to gain insight into the implications of LINE expression for human evolution and disease.

ISSN 

1471-2164

Link 

http://dx.doi.org/10.1186/1471-2164-7-139

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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