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Title 

Role of E2F1 in endoplasmic reticulum stress signaling

Authors 

Kyung Mi ParkDong Joon KimSang Gi PaikSoo Jung KimYoung Il Yeom

Publisher 

Springer Verlag (Germany)

Issue Date 

2006

Citation 

Molecules and Cells, vol. 21, no. 3, pp. 356-359

Keywords 

E2F1endoplasmic reticulum stresseukaryotic translation initiation factor 2α (eIF2α)thapsigargintranscription factor E2F1endoplasmic reticulumstressE2F1 transcription factor

Abstract 

The transcription factor E2F1 coordinates cell cycle progression and induces apoptosis in response to DNA damage stress. Aside from DNA damage, the role of E2F1 in the endoplasmic reticulum (ER) stress signaling pathways is unclear. We found that E2Fl-/- murine embryonic fibroblasts (MEFs) are resistant to apoptosis triggered by the ER stress inducer thapsigargin. In addition, E2F1 deficiency results in enhanced phosphorylation of eukaryotic translation initiation factor 2α (eIF2α). These results therefore indicate that E2F1 deficiency increases phosphorylation of eIF2α in response to ER stress triggered by thapsigargin, and suggest that the reduction in ER stress-induced apoptosis. in E2F1 deficient cells is related to the high level of eIF2α phosphorylation.

ISSN 

1016-8478

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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