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Title 

Expression of hepatitis C virus nonstructural 4B in transgenic mice

Authors 

A G WangH B MoonJ M KimS B HwangDae Yeul YuDong Seok Lee

Publisher 

Korean Society of Medical Biochemistry

Issue Date 

2006

Citation 

Experimental and Molecular Medicine, vol. 38, no. 3, pp. 241-246

Keywords 

hepaciviruslivermice, transgenicNs4 protein, hepatitis C virusviral nonstructural proteinsprotein NS4Bunclassified drugvirus proteinvirus vectorcarcinogenicity

Abstract 

Hepatitis C virus (HCV) is a pathogen that is of great medical significance in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma worldwide. Although the HCV proteins have been intensively investigated over the past decade, the biochemical functions of the NS4B protein are still largely unknown. To investigate NS4B as a potential causative agent of liver disease, transgenic mice expressing the NS4B protein in liver tissue were produced. The transgenic animals were phenotypically similar to their normal littermates for up to 18 months of age. Our results suggest that the HCV NS4B protein is not directly cytopathic or oncogenic in our transgenic mice model.

ISSN 

1226-3613

Link 

http://dx.doi.org/10.1007/BF02968570

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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