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Title 

Homogeneous versus heterogeneous probes for microbial ecological microarrays

Authors 

Jin-Woo BaeYong Ha Park

Publisher 

Elsevier

Issue Date 

2006

Citation 

Trends in Biotechnology, vol. 24, no. 7, pp. 318-323

Keywords 

microarraysmicrobial genomesmicrobial identification probesoligonucleotide probesDNA microarrayDNA probeecological nichemicroarray analysismicrobial ecological microarraymicrobial genetics

Abstract 

Microbial ecological microarrays have been developed for investigating the composition and functions of microorganism communities in environmental niches. These arrays include microbial identification microarrays, which use oligonucleotides, gene fragments or microbial genomes as probes. In this article, the advantages and disadvantages of each type of probe are reviewed. Oligonucleotide probes are currently useful for probing uncultivated bacteria that are not amenable to gene fragment probing, whereas the functional gene fragments amplified randomly from microbial genomes require phylogenetic and hierarchical categorization before use as microbial identification probes, despite their high resolution for both specificity and sensitivity. Until more bacteria are sequenced and gene fragment probes are thoroughly validated, heterogeneous bacterial genome probes will provide a simple, sensitive and quantitative tool for exploring the ecosystem structure.

ISSN 

0167-7799

Link 

http://dx.doi.org/10.1016/j.tibtech.2006.04.010

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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