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Title 

Phellinsin A from Phellinus sp. PL3 exhibits antioxidant activities

 

목질진흙버섯으로부터 분리한 페린신 A가 나타내는 항산화 활성

Authors 

E I HwangJ R KimTae Sook JeongSangku LeeMun Chual RhoSung Uk Kim

Publisher 

Georg Thieme Verlag

Issue Date 

2006

Citation 

Planta Medica, vol. 72, no. 6, pp. 572-575

Keywords 

1,1 diphenyl 2 picrylhydrazyl2,2' azobis(2 methylpropionamidine) dihydrochloridephellinsin aplant extractthiobarbituric acid reactive substanceunclassified drugantioxidant activity

Abstract 

Phellinsin A, which was isolated from the culture broth of Phellinus sp. PL3, exhibited significant low-density lipoproteins (LDL)-antioxidant activity. It inhibited the Cu2+-mediated oxidation of LDL (IC50: 5.3 μM) and 2,2′-azobis(2-methylpropionamidine) dihydrochloride (AAPH)-mediated oxidation of LDL (IC50: 2.8 μM) in the thiobarbituric acid-reactive substances (TBARS) assay as well as the macrophage-mediated LDL oxidation (73% inhibition at 5 μM). In addition, it delayed LDL oxidation with a prolonged lag time (192 min at 2 μM, control: 44 min). This compound also showed a 10-fold more potent 1,1-diphenyl-2- picrylhydrazyl (DPPH) free radical scavenging activity (IC50: 1.7 μM) than trolox (IC50: 18.6 μM), a known DPPH inhibitor. In addition, phellinsin A inhibited xanthine oxidase activity with an IC 50 value of 31.0 μM, whereas allopurinol, a xanthine oxidase inhibitor, showed an IC50 value of 40.7 μM.

ISSN 

0032-0943

Link 

http://dx.doi.org/10.1055/s-2006-931533

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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