상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

E2-EPF UCP targets pVHL for degradation and associates with tumor growth and metastasis

Authors 

Cho Rok JungK S HwangJ YooWon Kyung ChoJ M KimW H KimDong Soo Im

Publisher 

Nature Publishing Group

Issue Date 

2006

Citation 

Nature Medicine, vol. 12, no. 7, pp. 809-816

Keywords 

breast tumormetastasisprotein degradationtumor celltumor cell linetumor growthcell line, tumorneoplasm metastasisvon hippel-lindau tumor suppressor protein

Abstract 

The von Hippel-Lindau tumor suppressor, pVHL, forms part of an E3 ubiquitin ligase complex that targets specific substrates for degradation, including hypoxia-inducible factor-1α (HIF-1α), which is involved in tumor progression and angiogenesis. It remains unclear, however, how pVHL is destabilized. Here we show that E2-EPF ubiquitin carrier protein (UCP) associates with and targets pVHL for ubiquitin-mediated proteolysis in cells, thereby stabilizing HIF-1α. UCP is detected coincidently with HIF-1α in human primary liver, colon and breast tumors, and metastatic cholangiocarcinoma and colon cancer cells. UCP level correlates inversely with pVHL level in most tumor cell lines. In vitro and in vivo, forced expression of UCP boosts tumor-cell proliferation, invasion and metastasis through effects on the pVHL-HIF pathway. Our results suggest that UCP helps stabilize HIF-1α and may be a new molecular target for therapeutic intervention in human cancers.

ISSN 

1078-8956

Link 

http://dx.doi.org/10.1038/nm1440

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)