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Title 

Tumor necrosis factor-α and interleukin-1β increases CTRP1 expression in adipose tissue

Authors 

K Y KimH Y KimJ H KimChul Ho LeeD H KimY H LeeS H HanJ S LimD H ChoM S LeeS YoonK I KimD Y YoonY Yang

Publisher 

Elsevier

Issue Date 

2006

Citation 

FEBS Letters, vol. 580, no. 16, pp. 3953-3960

Keywords 

adipokineCTRPproinflammatory cytokinesinterleukin 1tumor necrosis factor alphaadipose tissueanimal tissuegene expressiongene expression profilinggene expression regulation

Abstract 

CTRP1, a member of the CTRP superfamily, consists of an N-terminal signal peptide sequence followed by a variable region, a collagen repeat domain, and a C-terminal globular domain. CTRP1 is expressed at high levels in adipose tissues of LPS-stimulated Sprague-Dawley rats. The LPS-induced increase in CTRP1 gene expression was found to be mediated by TNF-α and IL-1β. Also, a high level of expression of CTRP1 mRNA was observed in adipose tissues of Zucker diabetic fatty (fa/fa) rats, compared to Sprague-Dawley rats in the absence of LPS stimulation. These findings indicate that CTRP1 expression may be associated with a low-grade chronic inflammation status in adipose tissues.

ISSN 

0014-5793

Link 

http://dx.doi.org/10.1016/j.febslet.2006.06.034

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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