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Title 

Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors

 

PRL-3의 inhibitor인 rhodanine유도체들의 합성과 생물학적 평가

Authors 

J H AhnSeung Jun KimW S ParkS Y ChoJ D HaS S KimS K KangDae Gwin JeongSuk-Kyeong JungSang-Hyeup LeeHwan Mook KimSong Kyu ParkKiho LeeChang Woo LeeSeong Eon RyuJ K Choi

Publisher 

Elsevier

Issue Date 

2006

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 16, no. 11, pp. 2996-2999

Keywords 

cancerinhibitormetastasisPRL-3rhodaninebenzylidene derivativeprotein tyrosine phosphatase inhibitorregenerating liver 3 phosphatase inhibitordrug synthesis

Abstract 

A series of rhodanine derivatives was synthesized and evaluated for their ability to inhibit PRL-3. Benzylidene rhodanine derivative showed good biological activity, while compound 5e was the most active in this series exhibiting an IC50 value of 0.9 μM in vitro and showed a reduced invasion in cell-based assay.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2006.02.060

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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