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Title 

Berberine, a natural plant product, activates AMP-activated protein kinase With beneficial metabolic effects in diabetic and insulin-resistant states

Authors 

Y S LeeW S KimK H KimM J YoonH J ChoY ShenJ M YeChul Ho LeeWon Keun OhChul Tae KimC Hohnen-BehrensA GosbyE W KraegenD E JamesJ B Kim

Publisher 

American Diabetes Association

Issue Date 

2006

Citation 

Diabetes, vol. 55, no. 8, pp. 2256-2264

Keywords 

AICAR, 5-aminoimidazole-4-carboxamide ribosideAMPK, AMP-activated protein kinaseDMEM, Dulbecco's modified Eagle's mediumFAS, fatty acid synthaseMAPK, mitogen-activated protein kinasePI, phosphatidylinositolberberineFas antigenglucose transporter 4hydroxymethylglutaryl coenzyme A reductase kinase

Abstract 

Berberine has been shown to have antidiabetic properties, although its mode of action is not known. Here, we have investigated the metabolic effects of berberine in two animal models of insulin resistance and in insulin-responsive cell lines. Berberine reduced body weight and caused a significant improvement in glucose tolerance without altering food intake in db/db mice. Similarly, berberine reduced body weight and plasma triglycerides and improved insulin action in high-fat-fed Wistar rats. Berberine downregulated the expression of genes involved in lipogenesis and upregulated those involved in energy expenditure in adipose tissue and muscle. Berberine treatment resulted in increased AMP-activated protein kinase (AMPK) activity in 3T3-L1 adipocytes and L6 myotubes, increased GLUT4 translocation in L6 cells in a phosphatidylinositol 3′ kinase-independent manner, and reduced lipid accumulation in 3T3-L1 adipocytes. These findings suggest that berberine displays beneficial effects in the treatment of diabetes and obesity at least in part via stimulation of AMPK activity.

ISSN 

0012-1797

Link 

http://dx.doi.org/10.2337/db06-0006

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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