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Title 

Macrolactin N, a new peptide deformylase inhibitor produced by Bacillus subtilis

Authors 

Jung-Sung YooC J ZhengSangku LeeJ H KimWon Gon Kim

Publisher 

Elsevier

Issue Date 

2006

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 16, no. 18, pp. 4889-4892

Keywords 

antibacterialmacrolactinpeptide deformylaseS. aureuslactone derivativemacrolactin npeptide deformylase inhibitorunclassified drugantibacterial activitybacillus subtilis

Abstract 

A new 24-membered ring lactone, macrolactin N, was isolated from a culture broth of Bacillus subtilis and its structure was established by various spectral analysis. Macrolactin N inhibited Staphylococcus aureus peptide deformylase with an IC50 value of 7.5 μM and also showed antibacterial activity against Escherichia coli and S. aureus.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2006.06.058

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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