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Title 

Fatty acid synthase inhibitory activity of acylphloroglucinols isolated from Dryopteris crassirhizoma

Authors 

Min Kyun NaJunPil JangB S MinS J LeeM S LeeBo Yeon KimWon Keun OhJong Seog Ahn

Publisher 

Elsevier

Issue Date 

2006

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 16, no. 18, pp. 4738-4742

Keywords 

acylphloroglucinolsdryopteridaceaedryopteris crassirhizomaFAS inhibitorsfatty acid synthase (FAS)fatty acid synthase inhibitorfilixic acidflavaspidic acidnorflavaspidic acidantineoplastic activity

Abstract 

Fatty acid synthase (FAS) is emerging as a potential therapeutic target to treat cancer and obesity. Bioassay-guided fractionation of a MeOH extract of the rhizomes of Dryopteris crassirhizoma (Dryopteridaceae), using an in vitro FAS inhibitory assay, resulted in the isolation of a series of acylphloroglucinols, as the active principles. The isolates 1-10 inhibited FAS with IC50 values ranging from 23.1 ± 1.4 to 71.7 ± 3.9 μM. The results of the present study indicate that the acylphloroglucinol derivatives could be considered to be a promising class of FAS inhibitors.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2006.07.018

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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