상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Synthesis of 13-(substituted benzyl) berberine and berberrubine derivatives as antifungal agents

Authors 

Ki Duk ParkJ H LeeS H KimTae Hoon KangJae Sun MoonSung Uk Kim

Publisher 

Elsevier

Issue Date 

2006

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 16, no. 15, pp. 3913-3916

Keywords 

13-(Substituted benzyl) berberine13-(Substituted benzyl) berberrubineantifungal activityantifungal agentberberine derivativedrug synthesisantifungal agentsberberine

Abstract 

By introducing various aromatic groups in 13-C of berberine and berberrubine, a series of 13-(substituted benzyl) berberine and berberrubine derivatives were synthesized and examined for antifungal activities against various human pathogenic fungi. The synthesized compounds exhibited more potent antifungal activities than berberine and berberrubine. Among them, 13-(4-isopropyl benzyl) berberine (6e) exerted the most potent antifungal activities against Candida species (MIC = 1-8 μg/ml) and a 4-fold stronger activity than 13-(4-isopropyl benzyl) berberrubine (7e) synthesized by pyrolysis of compound 6e.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2006.05.033

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)