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Title 

Observation of self-assembled fluorescent beads by scanning near-field optical microscopy and atomic force microscopy

Authors 

Y J OhW JoMin-Gon KimHyun Kyu ParkBong Hyun Chung

Publisher 

Elsevier

Issue Date 

2006

Citation 

Ultramicroscopy, vol. 106, no. 8, pp. 775-778

Keywords 

beadsfluorescence detectionself-assembled monolayersSNOMatomic force microscopyoptical microscopyscanning near-field optical microscopy (SNOM)self assemblyscanning near field optical microscopy

Abstract 

Optical response and topography of fluorescent latex beads both on flat self-assembled monolayer and on a micron-patterned surface with poly(dimethylsiloxane) are studied. Scanning near-field optical microscopy and atomic force microscopy were utilized together for detecting fluorescence and imaging topography of the patterned latex beads, respectively. As a result, the micro-patterned latex beads where a specific chemical binding occurred show a strong signal, whereas no signals are observed in the case of nonspecific binding. With fluorescein isothiocyanate (FITC), it is convenient to measure fluorescence signal from the patterned beads allowing us to monitor the small balls of fluorescent latex.

ISSN 

0304-3991

Link 

http://dx.doi.org/10.1016/j.ultramic.2005.12.014

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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