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Title 

Isolation of flavonoids, a biscoumarin and an amide from the flower buds of Daphne genkwa and the evaluation of their anti-complement activity

 

원화의 flavonoids, biscoumarin, amide 분리와 항보체 활성

Authors 

Bo-Young ParkB S MinSei Ryang OhJung Hee KimK H BaeHyeong Kyu Lee

Publisher 

Wiley-Blackwell

Issue Date 

2006

Citation 

Phytotherapy Research, vol. 20, no. 7, pp. 610-613

Keywords 

anti-complement activitydaphne genkwadaphnoretin7 methoxyacacetinamideapigeninapigenin 5 o beta dextro glucopyranosideapigenin 7 o beta dextro glucuronideaurantiamide acetatecoumarin

Abstract 

As part of an ongoing study aimed at identifying the anti-complement active compound from the flower buds of Daphne genkwa, ten flavonoids, one biscoumarin and one amide were isolated. Their structures were identified from spectroscopic and physicochemical data as genkwanin 5-O-β-D-primveroside (1), apigenin 7-O-β-D-glucuronide (2), genkwanin 5-O-β-D- glucopyranoside (3), apigenin 5-O-β-D-glucopyranoside (4), genkwanin (5), apigenin (6), luteolin 7-methyl ether (7), luteolin (8), daphnoretin (9), velutin (10), 7-methoxyacacetin (11) and aurantiamide acetate (12). Among them, compounds 9, 10 and 12 were isolated from this plant for the first time. The anti-complement activity of these compounds was tested against the classical pathway of the complement system. Among the compounds, daphnoretin (9) exhibited significant anti-complement activity with an IC50 value of 11.4 μM, whereas the other compounds were not active in the assay.

ISSN 

0951-418X

Link 

http://dx.doi.org/10.1002/ptr.1915

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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