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Title 

Indenone derivatives: A novel template for peroxisome proliferator- activated receptor γ (PPARγ) agonists

Authors 

J H AhnM S ShinS H JungS K KangK R KimS D RheeW H JungS D YangSeung Jun KimJ R WooJeong-Hyung LeeH G CheonS S Kim

Publisher 

American Chemical Society

Issue Date 

2006

Citation 

Journal of Medicinal Chemistry, vol. 49, no. 15, pp. 4781-4784

Keywords 

1 oxo 3 phenyl 6 (3 phenylpropoxy) 1h indene 2 carboxylic acid ethyl esterindenone derivativeperoxisome proliferator activated receptor gamma agonistunclassified drugdiabetes mellitusdrug activityanimalscrystallography, X-rayhumansligands

Abstract 

Agonists of peroxisome proliferator-activated receptor γ(PPAR γ) are of interest as a treatment for diabetes, which prompted the identification of a new class of non-TZD PPAR γ agonist. Moreover, compound 14c has displayed the most active agonistic activity with an EC 50 value of 50 nM, in addition to exhibiting a new binding mode in the X-ray cocrystal structure.

ISSN 

0022-2623

Link 

http://dx.doi.org/10.1021/jm060389m

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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