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Title 

Neopikromycin and novapikromycin from the pikromycin biosynthetic pathway of Streptomyces venezuelae

Authors 

S K LeeJ W ParkJ W KimW S JungS R ParkC Y ChoiE S KimB S KimJong Seog AhnD H ShermanY J Yoon

Publisher 

American Chemical Society

Issue Date 

2006

Citation 

Journal of Natural Products, vol. 69, no. 5, pp. 847-849

Keywords 

neopikromycinnovapikromycinpikromycinstreptomyces venezuelaestreptomyces

Abstract 

Two new macrolides from the pikromycin biosynthetic pathway of Streptomyces venezuelae, neopikromycin (9) and novapikromycin (10), were identified and structurally characterized through mass spectrometry and NMR spectroscopy. The established structures showed that 9 and 10 have hydroxyl groups at C-14 (9) and at both C-12 and C-14 (10), on the basis of a comparison with narbomycin (7). The purified PikC cytochrome P450 monooxygenase catalyzes the in vitro hydroxylation of 7 and pikromycin (8) to yield 9 and 10, respectively, thus expanding the substrate- and regio-flexibility of this enzyme.

ISSN 

0163-3864

Link 

http://dx.doi.org/10.1021/np060026p

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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