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Title 

SNP@Domain: a web resource of single nucleotide polymorphisms (SNPs) within protein domain structures and sequences

Authors 

Areum HanH J KangY ChoSung Hoon LeeYoung Joo KimSungsam Gong

Publisher 

Oxford University Press

Issue Date 

2006

Citation 

Nucleic Acids Research, vol. 34, no. W, pp. W642-W644

Keywords 

computer graphicscomputer interfacecomputer programhumanprotein databaseprotein tertiary structuresequence analysissingle nucleotide polymorphismdatabases, protein

Abstract 

The single nucleotide polymorphisms (SNPs) in conserved protein regions have been thought to be strong candidates that alter protein functions. Thus, we have developed SNPΔomain, a web resource, to identify SNPs within human protein domains. We annotated SNPs from dbSNP with protein structure-based as well as sequence-based domains: (i) structure-based using SCOP and (ii) sequence-based using Pfam to avoid conflicts from two domain assignment methodologies. Users can investigate SNPs within protein domains with 2D and 3D maps. We expect this visual annotation of SNPs within protein domains will help scientists select and interpret SNPs associated with diseases. A web interface for the SNPΔomain is freely available at http://snpnavigator.net/ and from http://bioportal.net/.

ISSN 

0305-1048

Link 

http://dx.doi.org/10.1093/nar/gkl323

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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