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Title 

Inhibition of protein tyrosine phosphatase 1B by lignans from Myristica fragrans

Authors 

S YangMin Kyun NaJun Pil JangKyung Ah KimBo Yeon KimN J SungWon Keun OhJong Seog Ahn

Publisher 

Wiley-Blackwell

Issue Date 

2006

Citation 

Phytotherapy Research, vol. 20, no. 8, pp. 680-682

Keywords 

meso-dihydroguaiaretic acidmyristica fragransotobaphenolPTP1Btype 2 diabetesprotein tyrosine phosphatase 1Bprotein tyrosine phosphatase 1B inhibitorenzyme inhibitionmyristicaceaeprotein phosphorylation

Abstract 

Inhibition of protein tyrosine phosphatase 1B (PTP1B) has been proposed as one of the drug targets for treating type 2 diabetes and obesity. Bioassay-guided fractionation of a MeOH extract of the semen of Myristica fragrans Houtt. (Myristicaceae) afforded PTP1B inhibitory compounds, meso-dihydroguaiaretic acid (1) and otobaphenol (2). Compounds 1 and 2 inhibited PTP1B with IC50 values of 19.6 ± 03 and 48.9 ± 0.5 μM, respectively, in the manner of non-competitive inhibitors. Treatment with compound 1 on 32D cells overexpressing the insulin receptor (IR) resulted in a dose-dependent increase in the tyrosine phosphorylation of IR. These results indicate that compound 1 can act as an enhancing agent in intracellular insulin signaling, possibly through the inhibition of PTP1B activity.

ISSN 

0951-418X

Link 

http://dx.doi.org/10.1002/ptr.1935

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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