상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Phenanthroquinolizidine alkaloids from the roots of Boehmeria pannosa potently inhibit hypoxia-inducible factor-1 in AGS human gastric cancer cells

Authors 

X F CaiX JinD LeeY T YangKyeong LeeYoung-Soo HongJ H LeeJung Joon Lee

Publisher 

American Chemical Society

Issue Date 

2006

Citation 

Journal of Natural Products, vol. 69, no. 7, pp. 1095-1097

Keywords 

alkaloid derivativeboehmeria pannosa extracthypoxia inducible factor 1hypoxia inducible factor 1alphahypoxia inducible factor 1betaphenanthroquinolizidine alkaloidprotein inhibitorcancer cellhumanhuman cell

Abstract 

A bioassay-guided phytochemical investigation on the methanol extract of Boehmeria pannosa, using a HIF-1-mediated reporter gene assay, led to the isolation of two phenanthroquinolizidine alkaloids, (-)-cryptopleurine (1) and (-)-(15R)-hydroxycryptopleurine (2). The structure of the new compound 2 was determined by spectroscopic methods. Compounds 1 and 2 potently inhibited the hypoxia-induced expression of a reporter gene under the control of a hypoxia response element (HRE) with IC50 values of 8.7 and 48.1 nM, respectively. Furthermore, 1 and 2 suppressed the accumulation of HEF-1α protein in a dose-dependent manner, but not the HIF-1β protein and inhibited expression of vascular endothelial growth factor (VEGF) by hypoxia.

ISSN 

0163-3864

Link 

http://dx.doi.org/10.1021/np060081y

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)