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Title 

Anti-atherosclerotic effect of a new synthetic functional oil containing mono-and diacylglycerol from corn oil

Authors 

K H ChoJong Min HanTae Sook JeongHyoung-Chin KimJ H LeeK T Lee

Publisher 

Karger

Issue Date 

2006

Citation 

Annals of Nutrition and Metabolism, vol. 50, no. 5, pp. 467-475

Keywords 

atherosclerosisdiacylglyceridehypercholesterolemialipoproteinsmonoacylglyceridecholesterol acyltransferasecorn oildiacylglycerolmonoacylglycerolphospholipase A2

Abstract 

Synthetic oil containing diacylglycerol and monoacylglycerol, called 'functional oil' (FO), was newly produced and evaluated for its putative anti-atherosclerotic potential by in vitro assays and in vivo test using hypercholesterolemic mice (C57BL/6). The FO revealed good inhibitory activities against both liver acyl-CoA:cholesterol acyltransferase and serum lipoprotein-associated phospholipase A2. The FO showed enhanced activities on lipoprotein interaction such as HDL particle rearrangement to produce different sizes of HDL species. In control mice, hypercholesterolemia was induced by consumption of high-cholesterol, high-fat (HCHF) diet that contained 1.25% cholesterol/15% fat/0.5% Na-cholate with or without 5% of corn oil. In experimental mice, 5% of the FO + HCHF diet was fed during the same period. After the 4-week administration of the diet, serum total cholesterol concentration of the FO-fed group decreased by 38 or 20% when compared to the HCHF diet control group or corn oil (99.9% of triacylglycerol) diet group, respectively. The percentage of HDL cholesterol to total cholesterol was 36% of HDL cholesterol in the FO-fed group, while the HCHF control group and corn oil-fed group showed 21 and 25%, respectively. These results indicate that the FO possesses a blood cholesterol-lowering effect in mouse model and inhibition effects against the atherogenic enzymes.

ISSN 

0250-6807

Link 

http://dx.doi.org/10.1159/000095353

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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